Pregnenolone
 
Name: Pregnenolone
Chemical Name: 5- pregnen-3β- alcohol-20-one
Molecular Formula: C21H32O2
Molecular weight: 316.49
CAS#: 145-13-1
Appearance: white or almost white crystalline powder
Specification: 99%HPLC


Specification
 

Item	Specification
Appearance	White or almost white crystalline powder or colorless crystals
Solubility	Practically insoluble in water, soluble in ethanol, sparingly soluble in acetone and fatty oil
Identification	IR: Complies with the reference spectrum
	TLC: Complies
Specific optical rotation	+186° to +194°(Calculated on the dry basis)
Related substances	Total impurities:≤0.8%
	Impurity A: ≤0.5%
	Impurity B: ≤0.5%
	Impurity C: ≤0.5%
	Impurity D: ≤0.5%
	Impurity E: ≤0.5%
	Impurity F: ≤0.5%
	Impurity G: ≤0.5%
	(Individual unidentified impurities): ≤0.10%
Loss on drying	≤0.5%
Assay(UV)	97.0% to 103.0%(Calculated on the dry basis)

 
General introduction:
 
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus.Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methylbranches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like all steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.

Application:
1. Used in the synthesis of steroid drug intermediate and steroid drugs;
2. Used as intermediate for the synthesis of progesterone, antiflamison;
3. With the same function of corticosteroids anti-inflammatory.
Package: 25kg/drum, inner package two plastic bags
Storage: Stored in cool and dry place. Keep away from light and heat.
Shelf life: 3 years if properly packaged.