99.9% Best Quality Powder Trilostane / Vetoryl CAS: 13647-35-3 for Treatment CAS NO.13647-35-3

Min.Order: 1 Kilogram
Payment Terms: T/T,

Product Details

Keywords

Trilostane
(4A 5A 17b) -3
17-Dihydroxy-4

Quick Details

ProName: 99.9% Best Quality Powder Trilostane /...
CasNo: 13647-35-3
Appearance: White Powder
Application: Trilostane can suppress cortical hormo...
ProductionCapacity: 5 Metric Ton/Day
Purity: 99% Min
Storage: Storage: Stored in a clean, cool, dry...
LimitNum: 1 Kilogram

Superiority

1. Mixed container, we can mix different items in one container.

2. Quality control, GC&HPLC&NMR Test.

3. Prompt shipment with professional documents.

4. Packing as your request, with photos before shipment.

5. High quality and competitive price

Details

Description:

Abstract:

Name: Trilostane
CAS No.: 13647-35-3
Formula: C20H27NO3
Molecular Weight: 329.48
EINECS: 237-133-0
Density: 1.25 g/cm3
Melting Point: 264 °C
Boiling Point: 497.8 °C at 760 mmHg

Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production of androstenedione, testosterone, and dihydrotestosterone in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

Specifications:

Test Item	Analysis Specification	Result
Description	White to off-white power	Conforms
Purity	98.5%min	99.20%
Water(K.F)	≤0.5%	0.20%
Loss on drying	≤0.5%	0.26%
Residue on ignition	≤0.1%	0.04%
Heavy metals	≤20ppm	<20ppm
Specific optional rotation	+137°~ +139°	+138.8°
Conclusion	Conform to Company Standard.

Uses:

Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.

Packaging & Shipping:

Package: Double plastic bag inside, aluminum foil bag or fiber drum outside.

Delivery Detail: Within one week

Storage: Stored in a clean, cool, dry area; keep away from strong, direct light.

Shelf Life: Two years when properly stored.